Is Ivermectin a Cancer Solution?
BY JOSEPH
MERCOLA TIMEMAY
12, 2022 PRINT
It’s been vilified as being
dangerous, useless or both, but extensive research shows that’s not true. This
study demonstrates potential for its use against a broad range of cancers.
Along with direct cytotoxic effects, it’s believed to help regulate the tumor
microenvironment, mediating immunogenic cell death.
Story
at-a-glance
·
Ivermectin has notable antitumor effects,
which include inhibiting proliferation, metastasis and angiogenic activity
in cancer cells
·
Ivermectin may target cancer in multiple ways,
including inducing apoptosis and autophagy while also inhibiting tumor stem
cells and reversing multidrug resistance
·
Along with direct cytotoxic effects, it’s
believed that ivermectin regulates the tumor microenvironment, mediating
immunogenic cell death
·
The development of an injectable form of
ivermectin, or liposomal ivermectin, could help overcome some of its
limitations regarding solubility, and open its use to a broader range of
cancers
·
Considering that the “war against cancer” has
been ongoing for decades, with little to show in terms of lives saved,
repurposing existing drugs with favorable safety profiles and notable
anticancer effects — like ivermectin — makes sense
Ivermectin is a widely used antiparasitic
drug that’s listed on the World Health Organization’s essential medicines list1 and
approved by the U.S. Food and Drug Administration. In low- and middle-income
countries, ivermectin is commonly used to treat parasitic diseases including
onchocerciasis (river blindness), strongyloidiasis and other diseases caused by
soil-transmitted helminthiasis, or parasitic worms.2
The drug is also used to treat scabies and
lice. It’s estimated that the total number of ivermectin doses distributed is
equal to one-third of the world’s population and, as such, “ivermectin at the
usual doses (0.2–0.4 mg/kg) is considered extremely safe for use in humans.”3
Ivermectin also has demonstrated antiviral
and anti-inflammatory properties and made headlines for its potential role in
treating COVID-194 — although much of
the positive press has been censored and falsely labeled misinformation.5 Now
researchers are highlighting another potential use for ivermectin, which is
equally as exciting as its potential role in COVID-19 — as an anticancer agent.
Ivermectin’s
Powerful Antitumor Effects
Ivermectin has notable antitumor effects,
which include inhibiting proliferation, metastasis and angiogenic activity in
cancer cells.6 It appears to
inhibit tumor cells by regulating multiple signaling pathways, which
researchers explained in the Pharmacological Research journal, “suggests that
ivermectin may be an anticancer drug with great potential.”7
Their graphic, below, shows the multiple
ways that ivermectin may target cancer, including inducing apoptosis and
autophagy while also inhibiting tumor stem cells and reversing multidrug
resistance. They stated that ivermectin “exerts the optimal effect when used in
combination with other chemotherapy drugs.”8
Pharmacol Res. 2021 Jan; 163: 105207
Many may not be aware that scientists
Satoshi ōmura and William C. Campbell won the Nobel Prize in Physiology or
Medicine in 2015 for their discovery of ivermectin.9 The
medicine is used to treat not only parasitic diseases like malaria but also
shows promise for treating asthma and neurological diseases, in addition to
cancer.
Along with direct cytotoxic effects, it’s
believed that ivermectin regulates the tumor microenvironment, mediating
immunogenic cell death — another reason for its promise as an anticancer agent.10 Research
suggests the drug may be useful for the following cancers:11
Ivermectin
Shows Promise Against Colorectal Cancer
A study published in Frontiers in
Pharmacology specifically highlighted ivermectin’s potential to fight
colorectal cancer, which is the third most common cancer worldwide.12 The
drug was found to inhibit colorectal cancer cell growth in a dose-dependent
manner as well as promote cell apoptosis.
Further, even at low doses of 2.5 and 5 µM,
ivermectin inducted cell arrest in colorectal cancer, leading researchers to
state, “[I]vermectin might be a new potential anticancer drug therapy for human
colorectal cancer and other cancers.”13 Considering
that the “war against cancer” has been ongoing for decades, with little to show
in terms of lives saved, repurposing existing drugs with favorable safety
profiles and notable anticancer effects — like ivermectin — makes sense.
The Pharmacological Research scientists
similarly noted, “Drug repositioning is a shortcut to accelerate the
development of anticancer drugs.”14 Not
only has ivermectin been shown to permeate tumor tissues effectively, but it
has a long history of successful use in humans. They explained that even when
doses were increased, no serious adverse effects were found:15
“[T]he broad-spectrum
antiparasitic drug IVM (ivermectin), which is widely used in the field of
parasitic control, has many advantages that suggest that it is worth developing
as a potential new anticancer drug. IVM selectively inhibits the proliferation
of tumors at a dose that is not toxic to normal cells and can reverse the MDR
[multidrug resistance] of tumors.
Importantly, IVM is an
established drug used for the treatment of parasitic diseases such as river
blindness and elephantiasis. It has been widely used in humans for many years,
and its various pharmacological properties, including long- and short-term
toxicological effects and drug metabolism characteristics are very clear. In
healthy volunteers, the dose was increased to 2 mg/Kg, and no serious adverse
reactions were found …”
Is
Liposomal Delivery a Game Changer?
The development of an injectable form of
ivermectin, or liposomal ivermectin, could help overcome some of its
limitations regarding solubility and open its use to a broader range of
cancers. The cancer immunotherapy treatment pembrolizumab, for instance, is
approved to treat PD-L1-positive, triple-negative breast cancer, which accounts
for only about 20% of cases.
As an immune checkpoint inhibitor, it works
best in so-called “hot” tumors, which are already infiltrated by T cells. If
ivermectin could be injected into the tumor, inducing T-cell infiltration into
the area and inducing immunogenic cancer cell death, it’s possible that it
could turn a “cold” tumor into a “hot” one, thereby making it more effectively
treated.16
Biotech company Mountain Valley MD has
developed a liposomal delivery system for ivermectin that they believe could
dramatically widen its treatment potential. In an interview with Medical Update
Online, Dennis Hancock, Mountain Valley MD president and CEO, explained:17
“So the business value
proposition really simply is, we take the best-selling and best-acting drugs
and expand their ability to be used on … more types of cancer on a broader
spectrum. So you still need the cancer drug and what our Ivectosol does is it
enables it to be used in a broader universe …
What’s really exciting about
the work that Mountain Valley MD is doing is we’re enabling drugs that have
already been proven in their efficacy and safety to do better and do more faster
— so we’re not asking people to ‘wait five years and see’…”
Most of the research involving ivermectin
for cancer to date involves oral or in-vitro administration. Mountain Valley MD
is conducting preclinical trials using liposomal ivermectin for metastatic
melanoma, non-small cell lung cancer, triple-negative breast cancer and
possibly bladder cancers. They also have plans to produce liposomal ivermectin
for use in human trials.18 In a news release,
Mike Farber, director of life sciences at Mountain Valley MD, stated:19
“The extensive research
supporting the drug ivermectin as effective in the inhibition of proliferation,
metastasis, and angiogenic activity in a variety of cancers, and as an
initiator of immunogenic cell death, is overwhelming. Imagine what is possible
when you have the world’s only human injectable form of ivermectin that can be
directly injected into a tumor or provided through more bio-available forms
such as intravenously.
We believe this will be
groundbreaking research with near-immediate application to be able to proceed
directly to human trials based on the safety and efficacy of ivermectin.”
Ivermectin tablets packaged for human use. (Natasha Holt/The
Epoch Times)
What
About Ivermectin for SARS-CoV-2?
In the U.S., ivermectin has been vilified as
a treatment for SARS-CoV-2, despite its impressive inhibitory effects on the
virus.20 Even the FDA has a dedicated webpage
warning “why you should not use ivermectin to prevent COVID-19.”21
It’s interesting to note, however, that
Africa has a lower number of cases, severity of disease, hospitalizations and
deaths than other areas of the world,22 which
may be due to using prophylactic medications for endemic infections —
ivermectin and others, such as sweet wormwood — that have successfully treated
COVID-19.
For instance, a study from Japan
demonstrated that just 12 days after doctors were allowed to legally prescribe
ivermectin to their COVID-19 patients, the cases dropped dramatically.23 The
chairman of the Tokyo Medical Association24 noticed
the low number of infections and deaths in Africa, where many use ivermectin
prophylactically and as the core strategy to treat river blindness.25 More
than 99% of people infected with river blindness live in 31 African countries.
Aside from these observations, a study
published in the March 2022 issue of the International Journal of Infectious
Diseases found that treatment with ivermectin reduced mortality in COVID-19
patients — and to a greater degree than remdesivir.26
Another recent investigation by Cornell
University, posted on the University’s preprint server January 20, 2022, found
ivermectin outperformed 10 other drugs against COVID-19, making it the most
effective against the Omicron variant.27 It
even outperformed nirmatrelvir (Paxlovid), which was granted emergency use
authorization against COVID-19 in December 2021.
Remdesivir costs between $2,340 and $3,120,28 and
nirmatrelvir costs $529 per treatment,29 while
ivermectin’s average treatment cost is $58.30 Do
you think this has anything to do with ivermectin’s vilification?
Dr. Pierre Kory, who is part of the group
that formed the Front Line COVID-19 Critical Care Working Group (FLCCC) to
advance early treatments for COVID-19, pleaded with the U.S. government early
on in the pandemic to review the expansive data on ivermectin to prevent
COVID-19, and to keep those with early symptoms from progressing and help
critically ill patients recover — to no avail.31,32
However, if you’d like to learn more about
its potential uses for SARS-CoV-2, FLCCC’s I-MASK+ protocol can be downloaded
in full,33 giving you
step-by-step instructions on how to prevent and treat the early symptoms of
COVID-19.
FLCCC also has protocols for at-home
prevention and early treatment, called I-MASS, which involves ivermectin,
vitamin D3, a multivitamin and a digital thermometer to watch your body
temperature in the prevention phase and ivermectin, melatonin, aspirin and
antiseptic mouthwash for early at-home treatment.
Household or close contacts of COVID-19
patients may take ivermectin (18 milligrams, then repeat the dose in 48 hours)
for post-exposure prevention.34 Whether
ivermectin’s potential as an anticancer agent will be stifled the same way it
was for COVID-19 remains to be seen, but it appears to be a compound that’s
worth watching as a potential powerful agent in the fight against cancer.
Originally published May 12,
2022 on Mercola.com
References
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1, 2 WHO March 31, 2021
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3 American Journal of Therapeutics:
July/August 2021 – Volume 28 – Issue 4 – p e434-e460
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4 In Vivo. Sep-Oct 2020;34(5):3023-3026. doi:
10.21873/invivo.12134
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5 Trial Site News November 27, 2021,
3:52
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6, 7, 8 Pharmacol Res. 2021 Jan; 163: 105207
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9, 20 Pharmacol Res. 2021 Jan; 163: 105207., Introduction
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10 Pharmacol Res. 2021 Jan; 163: 105207., 2.1 Breast cancer
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11 Pharmacol Res. 2021 Jan; 163: 105207., 2. The role of IVM
in different cancers
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12, 13 Front Pharmacol. 2021; 12: 717529
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14, 15 Pharmacol Res. 2021 Jan; 163: 105207., Summary
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16, 17, 18 Medical Update Online June 19, 2021
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19 Mountain Valley MD May 3, 2021
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21 U.S. Food and Drug Administration,
Why You Should Not Use Ivermetin to Prevent COVID-19
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22 AP News, November 19, 2021
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23 YouTube, November 23, 2021 Min 1:25
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24 Tokyo Web, August 13, 2021
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25 World Health Organization,
Onchocerciasis
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26 International Journal of Infectious
Diseases March 2022; 116(Supplement): S40
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27 Cornell University, January 20, 2022
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28 AJMC June 29, 2020
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29 Precision Vaccinations, November
19, 2021
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30 JAMA 2022;327(6):584-587
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31 FLCCC Alliance, Ivermectin & COVID-19
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32 Mountain Home May 1, 2021
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33 FLCCC Alliance, I-Mask+
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34 FLCCC Alliance, I-MASS
Views expressed in this article
are the opinions of the author and do not necessarily reflect the views of The
Epoch Times.